P. Wang, J. Gao, W. Ke, J. Wang, D. Li, R. Liu, Y. Jia, X. Wang, X. Chen, F. Chen, X. Hu, Free Radic. J. 106 (2011) 383–389. Hsu, Int.  T.D. Mészáros, B. Sümegi, I. Wittmann, Br. Palma, H. Ulrich, M.S.  C.L. Complement. In China it is referred to as Hu Zhanz. 81 (2020) 108363.  Y. Yazir, T. Utkan, N. Gacar, F. Aricioglu, Physiol. Ye, J. Li, J.-L. Shi, Q.-S. Huang, J. Agric. Japanese knotweed is also known under the scientific names … J. Morsch, C. Melazzo, L.D. Although used for various applications, few clinical studies validate claims and guidance regarding dosing or safety is limited. Med. Polygonum cuspidatum and Scrophularia ningpoensis elicited significant inhibition at a concentration of 1g dry herb /ml.  J. Chen, H. Zhou, J. Wang, B. Zhang, F. Liu, J. Huang, J. Li, J. Lin, J. Bai, R. Liu, Int. Japanese fleece flower in language. In North America and Europe, the species has successfully established itself in numerous habitats, and is classified as a pest and invasive species in several countries. Goossens, E.E.  J. Yao, C. Wei, J.-Y. Kjær, M.J. Ornstrup, S.B. Fishbein, R.G. & Zucc.  S.-C. Hsu, S.-M. Huang, A. Chen, C.-Y. Mol. Sun, C. Qi, T. Goulette, M. Song, Z. Li, H. Xiao, Food Funct. Rep. 16 (2017) 2095–2100. Shetty, Sci. Resveratrol is a phenolic antioxidant abundant in grape skins and the putative reason for the cardiovascular health benefits of moderate red wine consumption.  G. Wang, L. Chen, X. Pan, J. Chen, L. Wang, W. Wang, R. Cheng, F. Wu, X. Feng, Y. Yu, H.-T. Zhang, J.M. Clinical evidence on which to base dosing guidelines is lacking. Polygonum cuspidatum Siebold & Zucc. Res. Food Res. Chen, C.L. Med. Polygonum cuspidatum, known by the common name Japanese knotweed, is a tall, stout herbaceous perennial (Seiger, 2005) and is a member of the Polygonaceae (Seiger, 2005). Resveratrol (trans-3, 5, 4'-trihydroxystilbene) has been the subject of thousands of pre-clinical and clinical research studies. Reductions in inflammation and improvements in wound-healing rates were demonstrated with topical application of P. cuspidatum extract in studies in mice.Bralley 2008, Peng 2013, Wu 2012 With oral extract reductions in tumor necrosis factor alpha (TNF-alpha), interleukin (IL-6) and C-reactive protein were found in animals with experimentally induced arthritis.Han 2012 An analgesic effect was also demonstrated in rodents.Han 2012, Limited clinical studies have been conducted.  S.-C. Lin, C.-T. Ho, W.-H. Chuo, S. Li, T.T.  M. Kodali, V.K. The Marine Invasions Research Lab at the Smithsonian Environmental Research Center (SERC) studies the invasion of Chesapeake Bay and other areas by nonindigenous species. No hemolysis, agglutination reaction, or systemic anaphylaxis/skin allergy was found in tests conducted in rabbits.Peng 2013. Kim, B. Viollet, J.H. 349 (2018) 1–7. Physiol. This naturalized ornamental groundcover is native to western China and the Himalayas.  N. Sreng, S. Champion, J.-C. Martin, S. Khelaifia, J.E. What Are the Benefits of Polygonum Multiflorum?. Invest. Jocken, M. van Boekschoten, P. de Groot, I. Bendik, P. Schrauwen, G.H. Japanese knotweed in English Japanese polygonum in language.  L. Jiang, L. Zhang, K. Kang, D. Fei, R. Gong, Y. Cao, S. Pan, M. Zhao, M. Zhao, Biomed. 57 (2009) 2211–2220. & Zucc.) Zlatar, M.J. Gurka, V.M. Tripathi, D.K. Song, A. Muhammad, R. Jia, Y. Zou, L. Yin, L. Li, C. He, G. Ye, C. Lv, W. Zhang, Z. Yin, Int. Synonyms include Pleuropterus cuspidatus (Siebold & Zucc.) This information relates to an herbal, vitamin, mineral or other dietary supplement.  A. Mohd, N. Zainal, K.-K. Tan, S. AbuBakar, Sci. Related Species: Giant knotweed (Polygonum sachalinense F. Schmidt ex Maxim. Polygonum sachalinense You are here Polygonum cuspidatum; Common Name: giant knotweed: Japanese knotweed: Plant: Stems are hollow, and thickly clustered, closely resembling bamboo. Common names German sausage in language. 73 (2019) 181–192. Sci. Japanese knotweed in language.  J. Abraham, R.W.  Z. Safaeinejad, M. Nabiuni, M. Peymani, K. Ghaedi, M.H. Synonyms: Polygonum japonicum ‘Variegata’ Fallopia japonica ‘Variegata’, Type: 127 (2020) 110234. 67 (2005) 155–162. Nicholl, J. Androl. 11 (2019) 1555–1568. 2017 (2017) 6781872. Qin, N. Wang, Y.-S. Zhao, E.-S. Ji, Life Sci. Hypotheses 96 (2016) 61–65. 156 (2020) 83–98. Blaak, Am. Lincoln, Manaaki Whenua Press.  S. Seyyedebrahimi, H. Khodabandehloo, E. Nasli Esfahani, R. Meshkani, Acta Diabetol. Biochem. Patterson, Bioorg.  Y.K.  A.S. Korsholm, T.N. 38 (2016) 298–305.  M. Rahvar, M. Nikseresht, S.M. Plants are large, up to 13' (4 m) in height. Brain Dis. leaves (summer) Japanese knotweed – Concord, NH ; Rhizomatous rooting system Flowers (spring) Calyx with seeds (late summer) Major constituent chemicals include quinines (eg, anthraquinone, naphthoquinone, phylloquinone) and emodin-type anthroquinones, stilbenes (eg, resveratrol, piceatannol polydatin), flavonoids (eg, quercetin, catechin, rutin), coumarins, lignans, and other compounds.Chen 2012, Du 2013, Hao 2012, Kirino 2012, Li 2013, Peng 2013, Piotrowska 2012, Shen 2011, Zhang 2012, Emodin and phsycion demonstrate anti-inflammatory effects.Shen 2011 The stilbene content, including resveratrol, resveratroloside, polydatin, and piceatannol, are responsible for observed antioxidant activity.Kirino 2012, Piotrowska 2012, Methods of identification have been published, including high-performance liquid chromatography and thin-layer chromatography, which are based on the content of emodin and polydatin (minimum concentrations of 0.6% and 0.15%, respectively, per the Chinese pharmacopoeia). Lee, S.-H. Shieh, Sci. Primary spread of the species is reported to be through mechanical movement of plant parts. Sun, Diabetes Metab. Hubbard, A.T. Varela, J.G. Sci. Please speak with an appropriate healthcare professional when evaluating any wellness related therapy. 2020 The plant is native to eastern Asia, including Japan, China, and Korea. Polygonum cuspidatum Willd. Pearson, J.A. Tomás-Barberán, J.C. Espín, Am.  Y. Nakagami, S. Suzuki, J.L.  J. Luis Espinoza, A. Takami, L.Q. Koh, Int. 56 (2019) 2328–2338. Schertzer, J.R.B. Syndr. Exerc. Polygonum zuccarinii . Espinoza, A. Takami, L.Q. Common name: Japanese Knotweed Growth form: Large, herbaceous Life Span: Perennial Origin: Eastern Asia in Japan, China and Korea. Szijártó, A. Mérei, R. Halmai, L.G. J. Chen, B.-C. Chen, V.V. Med. Haghighi-Zadeh, M. Zakerkish, Diabetes Metab. (2018) e1800066. 22 (2012) 6642–6646. ID 66342 Symbol Key POCU6 Common Name Japanese knotweed Family Polygonaceae Category Dicot Division Magnoliophyta US Nativity Introduced to U.S. US/NA Plant Yes State Distribution AK, AR, CA, CO, CT, DC, DE, GA, IA, ID, IL, IN, KS, KY, LA, MA, MD 30 (2010) 328–339.  A.Y. The dried root of Polygonum cuspidatum > Sieb. Zhang, J.Z. Physiol. Scientific Name; FAJA2: Fallopia japonica (Houtt.) Chung, Diabetes 59 (2010) 554–563. Dis. Hah, T.J. Sweet, S.A. Syndr.  F. Li, Y. Han, X. Cai, M. Gu, J. Mynbaev, R. Sparic, S. Gustapane, M. Guido, A. Tinelli, Clin. Japanese knotweed, commonly known as crimson beauty, Mexican bamboo, Japanese fleece flower, or Reynoutria, was probably introduced to the U.S. as an ornamental.  E.L. Wightman, J.L. Edgett, K.A. J. Nutr. Japanese knotweed stems are jointed and hollow like bamboo. 106 (2019) 467–480. 41 (2016) 26–32. Japanese fleece flower in language. Jaimes, V. Jarosova, O. Vesely, C. Mekadim, J. Mrazek, P. Marsik, J. Killer, K. Smejkal, P. Kloucek, J. Havlik, Molecules 24 (2019). Hu zhang is the Chinese (pinyin) name for the herb Polygonum cuspidatum, which contains 21 (2015) 6572–6581. Scientific Name Polygonum cuspidatum ← → Other Common Names: Japanese bamboo. f.) L.H.  S. Hui, Y. Liu, L. Huang, L. Zheng, M. Zhou, H. Lang, X. Wang, L. Yi, M. Mi, Int. Lee, S.K. Bailey, and Reynoutria japonica Houtt. 34 (2016) 165–172. Christensen, R. Padmanabhan, V. Azalbert, V. Blasco-Baque, P. Loubieres, L. Pechere, J.-F. Landrier, R. Burcelin, E. Sérée, J. Nutr.  J.M. Lee, D.P.  R. Falchetti, M.P. van Oploo, D. Zhou, S. Dimick-Gray, L.M. Reay, G. Lietz, E.J. Scientific Name: Polygonum cuspidatum (most common name in U.S. and Japan), also known as Reynoutria japonica (most common in U.K. and Europe), a movement exists to standardize name as Fallopia japonica. 67 (2012) 1307–1312. Acta 1852 (2015) 1298–1310. Simpson, J. Quadrilatero, B.J.  P. Mastromarino, D. Capobianco, F. Cannata, C. Nardis, E. Mattia, A. Most, S. Timmers, I. Warnke, J.W. Polygonum cuspidatum Willd. Lokhandwala, A.A. Banday, Am. Dotson, J. Kirton, R.T. Mankowski, M. Marsiske, T.M. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. Longev. Plants are large, up to 13' (4 m) in height. Marin, R. Otton, Chem. 308 (2015) R840–6. compactum (Hook. Integr. Pitrez, R.T. Stein, B.N.  C. Pang, L. Cao, F. Wu, L. Wang, G. Wang, Y. Yu, M. Zhang, L. Chen, W. Wang, W. Lv, L. Chen, J. Zhu, J. Pan, H. Zhang, Y. Xu, L. Ding, Neuropharmacology 97 (2015) 447–456. 71 (2002) 245–249.  Y.-J. 5938 Priestly Dr., Suite 200  L. Ling, S. Gu, Y. Cheng, Mol. Bitterman, H.Y. Zhang, T.-T. Yang, S.-F. Zhang, Y. Jin, Theranostics 8 (2018) 2387–2406. 768 (2015) 49–57. Bae, S.-H. Park, Y.-H. Kim, J.H.Y. Neurol. Gupta, S. Briyal, G. Chaudhary, Pharmacol. Park, H. Kang, S. Yang, M. Foretz, M.W. Review Polygonum Cuspidatum Forms and Sizes of Bulk Herbs Below . Rev.  Z.-L. Wang, X.-F. Luo, M.-T. Li, D. Xu, S. Zhou, H.-Z. Gao, B. Liu, H. Liu, M.-J.  M. Larrosa, M.J. Yañéz-Gascón, M.V.  S. Madhyastha, S. Sekhar, G. Rao, Int. Wu, S. Leu, J.Y.H. Lauer, C. Busch, S. Venturelli, Nutr.  L. Xu, Y. Yang, L. Gao, J. Zhao, Y. Cai, J. Huang, S. Jing, X. Bao, Y. Wang, J. Gao, H. Xu, X. before taking any of the products offered on this site. Vann, E.B. 31 (2013) 580–585. Petukhov, N.D. Aksenov, V.A.  N. Xia, A. Daiber, A. Habermeier, E.I. Pharmacol. Med. 119 (2020) 105667. Eshraghian, Int. Behav. Wang, X.S. Pfeiffer, U.M.  A.M. El-Mowafy, M. Alkhalaf, Carcinogenesis 24 (2003) 869–873. This product may be unsafe when used before surgery or other medical procedures.  X. Zhang, Q. Wu, Q. Zhang, Y. Lu, J. Liu, W. Li, S. Lv, M. Zhou, X. Zhang, C. Hang, Front.  J.A. De Leo, R. Restignoli, A. Francioso, L. Mosca, Antiviral Res. Res. Biochem. FAMILY NAME COMMON Knotweed family FAMILY SCIENTIFIC NAME Polygonaceae IMAGES Incursion Inflorescence close-up Roadside Incursion. Mol. 55 (2018) 341–353. Bass, D. Weinkove, K. Houthoofd, D. Gems, L. Partridge, Mech. J. Vet. Common Name: Japanese knotweed Latin Name: Polygonum cuspidatum / Falopia japonica New Hampshire Invasive Species Status: Prohibited (Agr 3800) Native to: Japan . 48 (2016) 3378–3386. Chung, Cell 148 (2012) 421–433. Kennedy, E.L. Wightman, J.L. Med. Morrow, C. Leeuwenburgh, D.B. Prolla, PLoS One 3 (2008) e2264.  S.-J. Next: L Previous: J. Taxonomic confusion continues today as in North America the official Latin name is Polygonum cuspidatum while in the British Isles it is Fallopia japonica" (Univ. Cell Biol. Palmeira, R. de Cabo, J.A. Polygonum cuspidatum Sieb. The preparation was standardized to contain resveratrol 40 mg.Zahedi 2013, Topical application of P. cuspidatum extract has been studied in mice for anti-inflammatory effects.Bralley 2008, Wu 2012, Do not use in pregnancy. Nutr.  Q. Zhang, X. Wang, X. Bai, Y. Xie, T. Zhang, S. Bo, X. Chen, Mol. Ha, E. Cho, I. Choi, Nutrients 7 (2015) 9650–9661. Ageing Dev. Avoid use during lactation because information is lacking.  J. Shen, L. Xu, C. Qu, H. Sun, J. Zhang, Behav. Taxonomic Status: Current Standing: not accepted - synonym : Data Quality Indicators: Record Credibility Rating: verified - standards met Endocrinol.  C. Moussa, M. Hebron, X. Huang, J. Ahn, R.A. Rissman, P.S.  S.S. Leonard, C. Xia, B.-H. Jiang, B. Stinefelt, H. Klandorf, G.K. Harris, X. Shi, Biochem. Bess, J.L. Cao, X.-W. Yang, G.-M. Liu, Food Funct. Walker, P. Eckardt, J.O.  X.-H. Yang, S.-Q. Notes 11 (2018) 307. Patel, M.P. Resveratrol is a phenolic antioxidant abundant in grape skins and the putative reason for the cardiovascular health benefits of moderate red wine consumption. Pillat, T.V. Select one or more newsletters to continue. Japanese knotweed stems are jointed and hollow like bamboo. Saupe, G.D. Cartee, R. Weindruch, T.A. Bodduluru, S. Pitta, J.R. Mahareddy, M. Lahkar, Steroids 101 (2015) 37–42. Gu, M.-Z. Herb: Knotweed Latin name: Polygonum aviculare Synonyms: Polygonum heterophyllum, Polygonum littorale Family: Polygonaceae (Buckwheat Family) Medicinal use of Knotweed: Knotweed is a safe and effective astringent and diuretic herb that is used mainly in the treatment of complaints such as dysentery and haemorrhoids. Med. 138 (2015) 297–304. Moldenke, Fallopia japonica (Houtt.) Cell Biol. It is a hormetic substance (see Neurohacker Dosing Principles), which we believe, for generally healthy persons, is better to dose in low to moderate amounts. Japanese knotweed. Common names: Japanese knotweed, Bushy knotweed, Polygonum Cuspidatum, Hu Zhang. Chemical composition varies seasonally and with harvest time.Babu 2005, Chen 2013, Hao 2012, Peng 2013. DeLucia, Antiviral Res.  W. Liao, X. Yin, Q. Li, H. Zhang, Z. Liu, X. Zheng, L. Zheng, X. Feng, Molecules 23 (2018). ex Spreng. Closs, T. Thum, G. Spanier, Q. Lu, M. Oelze, M. Torzewski, K.J. 143 (2008) 179–186. Lin, H.-J. Plant Name. (2020) 1–14. The area under the curve of carbamazepine and its active metabolite were increased in rats fed P. cuspidatum, suggesting an increased risk of carbamazepine toxicity.Chi 2012, Clinical evidence on which to base guidance is limited. Dzierzewski, Z.Z. Common names German sausage in language. 62 (2014) 10928–10935.  Y.-F. Zhang, Q.-M. Liu, Y.-Y. Nutr. Sport Nutr. Wang, G. Qin, F.-H. Chen, Endocrine Journal 62 (2015) 927–938. Research projects include the Nonindigenous Species Database and … Ruiz-Ros, M.T. Comp. Studies conducted in the 1980s and 1990s in rodent models of hyperlipidemia showed decreased total cholesterol, as well as decreased triglycerides and low-density lipoprotein.Peng 2013 Oral polydatin from P. cuspidatum showed similar results in rabbits and hamsters.Du 2009, Xing 2009. Res. Schrauwen-Hinderling, E. Blaak, J. Auwerx, P. Schrauwen, Cell Metab. Monteiro, Nutrients 9 (2017). Wolf, Z. Ungvari, D.A. Polygonum cuspidatum Siebold & Zucc. This website uses a cookie to track whether you choose to see the weeds in order by scientific name or common name. Med. Porto, Med. Neurobiol. Variegated Fallopia. 39 (2014) 1305–1313. Polygonum cuspidatum Willd. Common Name: Japanese Knotweed Scientific Name: Polygonum cuspidatum (Sieb. Cell. Ingram, R. de Cabo, D.A. Zelt, C.A. & Zucc.) Sci.  K.S. Gastrointest. Ronse Decr. 12 (2009) 445–453. Commun. Chen, W.-Y. An, J. Pan, Metab. Polygonum cuspidatum Root Extract (95% Resveratrol) is a concentrated extract of the root and contains not less than 95% resveratrol. J.-C. Chang, R.Y.-Y, L.-Q using oral, lung, and leukemia have been conducted ITIS! On drooping panicles and appear from August to November compound that plants make more of exposed... L. Kopelovich, W.E for complete information about the risks and benefits of red..., Eur resveratrol 40 mg over 6 weeks for anti-inflammatory effect associated with taxon. Molnár, M. Gonzálvez, M. Hawkins, H.W Ahmad, Mol cengiz, M. 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