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  • 날짜 2020년 12월 22일

beta thalassemia vs alpha thalassemia

The diagnosis of beta thalassemia minor is made if the HbA 2 level is more than 3.5%. Persons with beta thalassemia major are diagnosed during infancy. Alpha thalassemia affects the amount of hemoglobin in the red blood cells. 3. Marion A. Koerper, MD UCSF School of Medicine San Francisco, CA. 2. In this form of beta thalassemia, two defective genes are passed to the child and the child has no normal beta.chain gene. Genetics – (see "Introduction to hemoglobin mutations" and "Molecular genetics of the thalassemia syndromes") The terms alpha and beta refer to the part of the hemoglobin the person is lacking. Alpha thalassemia, which is characterized by genetic defects in the alpha-globin gene, is another known cause of mild microcytic anemia and has features similar to those of beta thalassemia. Beta Thalassemia Trait/Minor. Beta Thalassemia Trait/Minor Beta thalassemia minor is a common condition which is symptomless most of the time. Pallor, irritability, growth retardation, abdominal swelling, and jaundice appear during the sec- Thalassemia can cause mild or severe anemia. Learn how to distinguish alpha thalassemia and beta thalassemia. People with beta-thalassemia major often have larger percentages of Hgb F. That is because beta-thalassemia affects the balance of alpha and beta hemoglobin chain formation greatly. The diagnosis of beta thalassemia minor is made if the HbA 2 level is more than 3.5%. Thalassemia is an inherited blood disorder that is passed down through the parent’s genes. Thalassemia Intermedia Adult hemoglobin (hemoglobin A) is made of alpha and beta globins. Beta thalassemia minor is a common condition which is symptomless most of the time. The two types are alpha thalassemia and beta thalassemia. So this child has alpha thalassemia silent carrier/beta thalassemia minor. Alpha thalassemia is common in people of African, Southern Chinese, Southeast Asian, Middle Eastern and Mediterranean descent. There is the deficiency of beta globin production in the body which leads to significant illness. with alpha thalassemia trait. Although the features are similar to those of alpha thalassemia, beta thalassemia is more severe than its counterpart. Thalassemia is a common cause of anemia, especially microcytic anemia. alpha thal trait is almost silent unless associated with an alpha ° thal.. Hb H) beta trait is a beta ° ones.. but since partner does not carry beta thal , there is no risk of severe beta genotype. The pathogenesis and treatment of alpha and beta thalassemia, including the role of hematopoietic cell transplantation (HCT), monitoring of iron stores, and iron chelation, are discussed in detail separately. Thalassemia Major or Cooley’s Anemia. Although the features are similar to those of alpha thalassemia, beta thalassemia is more severe than its counterpart. He is termed as homozygous for beta thalassemia. if it is less than 13 it is highly predictive of thalassemia; greater than 13 indicates an iron deficiency or anemia of inflammation Thalassemia Intermedia It causes an increase in minor hemoglobin components. Evaluation: Forms of disease diagnosed through gel-electrophoresis of globin chains; Unexplained finding is that although there is a decrease in the Hgb concentration and MCV, there is a normal or slightly increased RBC count ; Ratio used: Mentzer Ratio = MCV / RBC. The elevated Hgb A2 and Hgb F suggest beta-thalassemia trait. Also, remember that a person with beta-thalassemia minor often has a high number of Hgb A2. There are also terms for how serious the thalassemia is. There are two main types of thalassemia: alpha and beta. 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